Figure 10.

Ablation of Kcnq3 leads to hyperexcitability across the forebrain in the presence of 8 mm Ko. A, top panels, Two examples of acute slices from Kcnq3^+/+ and Kcnq3^−/− mice with one hemisphere segmented into ROIs. Below, 2D plots show the changes in the ΔF/F as a function of time for the different ROIs. Note that calcium activity is recorded across all regions in the Kcnq3-null slice. B, Raw traces show calcium activity (ΔF/F) across the different anatomic areas. Top two panels, Temporal evolution of LFPs and ΔF/F recorded in parallel from the CA3 region of the hippocampus. C, Violin plots show the effect of Kcnq3 deletion on the ΔF/F amplitude, duration, and event frequency (events/s) for the different anatomic regions. The median and the interquartile ranges are also shown (*p < 0.05, **p < 0.01, ****p < 0.0001). Additional details on the statistical analysis for panel C are found in Table 1 under the Figure 10 section.