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. 2021 May 10;12:618037. doi: 10.3389/fendo.2021.618037

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Copyright © 2021 Cheng, Zhang, Shang, Ning, Huang, He, Sun and Dong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of emodin on the lipid metabolites in BAT of HFD mice. (A) The content of Cer in BAT. (B) The content of PC in BAT. (C) The content of PE in BAT. (D) The ratio of PC : PE in BAT. (E) Heat map. Only metabolites with VIP >1 and P <0.05 were selected in heat map, and different shades of color present the concentration (red, white and blue presented the high, normal and low concentration). The red up arrow indicates up regulation or promotion. HFD, high fat diet; Emo, emodin; PC, Phosphatidylcholine; PE, phosphatidylethanolamine; Cer, ceramides. Data are expressed as mean ± SE. ^* P < 0.05, ^** P < 0.01 vs. HFD group.