Table 4.

Drug interactions.

	Dabigatran	Rivaroxaban	Apixaban	Edoxaban	Betrixaban
Drug interaction (inhibitors)	P-gp	Strong CYP3A4+P-gp	Strong CYP3A4+P-gp	P-gp	P-gp
Plasma concentration	↑	↑	↑	↑	↑
Dose adjustment	Reduce or avoid	Avoid	Reduce or avoid	Reduce (VTE)	Avoid: CrCL < 30 mL/min
Drug interaction (inducers)	P-gp	Strong CYP3A4 or P-gp	Strong CYP3A4 or P-gp	P-gp	P-gp
Plasma concentration	↓	↓	↓	↓	↓
Dose adjustment	Avoid	Avoid	Avoid	Avoid with Rifampin	No recommendation

VTE: venous thromboembolism; CrCL: creatinine clearance; P-gp, P-glycoprotein.