Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 10;9:650003. doi: 10.3389/fcell.2021.650003

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Mei, Mou, Liu and Xiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Possible mechanisms underlying the paracrine effect of human umbilical cord mesenchymal stem cells (HUMSCs). HUMSCs, HUMSCs-CM and HUMSCs-MVs all ameliorate ovarian senescence through paracrine effects. Regulation of Bax, Bcl-2, caspase-3 helps to inhibit apoptosis; VEGF, HGF, IGF-1 and angiopoietin play important roles in angiogenesis; Th1/Th2 cytokines play important roles in balanced local immune response; AMPK/mTOR signaling pathway plays an important role in antioxidant process. The mechanism of antifibrosis is not clear.