Table 3.
Top 10 CpG sites which have interaction between pack-years and sex and their main effects stratified by sex
| CpG site | Gene symbol | CHR | Gene location | Island location | PY * sex interaction |
Male (PY) |
Female (PY) |
||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Coefᶧ | P value | FDR | Coefᶧ | P value | Coefᶧ | P value | |||||
| cg20968821 | GPR132 | 14 | 5ʹUTR | OpenSea | −1.56E-03 | 2.54E-07 | 0.073 | −6.38E-04 | 8.40E-03 | 9.90E-04 | 6.78E-04 |
| cg09496748 | ANKRD44 | 2 | Body | Island | −1.82E-03 | 4.15E-07 | 0.073 | −8.43E-04 | 2.92E-03 | 1.13E-03 | 9.95E-04 |
| cg00667525 | C19orf60 | 19 | TSS1500 | N_Shore | −1.46E-03 | 8.29E-07 | 0.097 | −4.86E-04 | 1.93E-02 | 1.38E-03 | 1.32E-05 |
| cg10711775 | <NA> | 10 | Island | −1.40E-03 | 2.22E-06 | 0.158 | −6.96E-05 | 6.22E-01 | 1.73E-03 | 6.09E-07 | |
| cg07805999 | C7orf50 | 7 | Body | N_Shelf | 1.72E-04 | 2.26E-06 | 0.158 | 2.87E-05 | 7.15E-02 | −1.85E-04 | 8.60E-06 |
| cg10338830 | EMP3 | 19 | Body | Island | 2.81E-03 | 3.04E-06 | 0.167 | 1.55E-03 | 1.52E-03 | −1.06E-03 | 5.30E-02 |
| cg10414350 | MSRA | 8 | Body | OpenSea | −1.81E-03 | 3.59E-06 | 0.167 | −1.14E-03 | 7.67E-04 | 9.34E-04 | 5.37E-03 |
| cg03528353 | STRADA | 17 | TSS1500 | S_Shore | 9.50E-05 | 3.81E-06 | 0.167 | 5.81E-05 | 2.99E-03 | −5.01E-05 | 5.55E-03 |
| cg06776644 | SMCO4 | 11 | 5ʹUTR | OpenSea | −1.78E-03 | 4.81E-06 | 0.182 | −8.40E-04 | 4.57E-03 | 1.37E-03 | 4.69E-04 |
| cg08389588 | <NA> | 13 | OpenSea | −9.96E-04 | 5.70E-06 | 0.182 | −5.30E-04 | 2.14E-02 | 5.24E-04 | 1.40E-02 | |
Adjusted for age, sex, presence of COPD, smoking pack-years, and time since quit smoking, centre and plate number in addition to interaction between sex and pack-years
Abbreviations: PY, pack-years; TSS1500, 1500 bp blocks upstream of transcription start site; TSS200, 200 bp blocks upstream of transcription start site; 5ʹUTR, 5ʹ untranslated region; N_ and S_ denote the upstream and downstream end of the island region, respectively.
G protein-coupled receptor 132 (GPR132: cg20968821); ankyrin repeat domain 44 (ANKRD44: cg09496748); chromosome 19 open reading frame 60 (C19orf60: cg00667525); chromosome 7 open reading frame 50 (C7orf50: cg07805999); epithelial membrane protein 3 (EMP3: cg10338830); methionine sulphoxide reductase A (MSRA: cg10414350); STE20 Related Adaptor Alpha (STRADA: cg03528353); Single-Pass Membrane Protein With Coiled-Coil Domain 4 (SMCO4: cg06776644)