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. 2020 Sep 24;16(6):677–691. doi: 10.1080/15592294.2020.1819661

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This work was authored as part of the Contributor’s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.

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Figure 3. — Methylation and expression of AQP5 in tumour and adjacent normal tissue of breast cancer patients in Hong Kong (HK) and The Cancer Genome Atlas (TCGA) datasets. (a) Methylation increases with increasing age for the probe cg03020208 corresponding to the gene AQP5 in adjacent normal tissue in HK (n = 84) (left) and TCGA (n = 97) (right). (b) Gene expression decreases as age increases for AQP5 in HK (n = 92) (left) and TCGA (n = 83) (right). (c) Overall methylation levels in adjacent normal and tumour tissue for the AQP5 probe cg03020208 in HK (n = 85) (left) and TCGA (n = 82) (right). (d) Overall AQP5 expression levels in adjacent normal and tumour tissue in HK (n = 72) (left) and TCGA (n = 83) (right). (e) Methylation of AQP5 in tumour tissue by molecular subtype in HK (n = 70) (left) and TCGA (n = 63) (right) (f) Expression of AQP5 in tumour tissue by molecular subtype in HK (n = 116) (left) and TCGA (n = 505) (right)