Figure 1.

Schematic representation of different interventions to improve the therapeutic ratio. Interventions can either improve the radiosensitivity of the primary tumor or metastatic lesion or protect the healthy tissue. Influencing the differential stress response between tumor and normal healthy tissue can contribute to an enhanced therapeutic ratio. Different pathways and proteins can be influenced in relationship to enhancement of the therapeutic ratio, such as mitochondrial and glucose metabolism, ROS scavenging and redox signaling, hypoxia response, DNA repair capacity and inflammation.