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IMMH-010 metabolism in rat, dog, monkey, and human liver S9 fractions. IMMH-010 (10 μM) was incubated with liver S9 homogenate protein (0.5 mg protein/mL) and an NADPH regenerating system in a final volume of 0.2 mL Tris-HCl buffer (50 mM, pH 7.4) containing 5 mM MgCl2. IMMH-010 metabolism in the liver has interspecies similarities. Data are expressed as mean ± SD.
