Table 2.
Demographic data, cognitive functions and P300 parameters in clinical high-risk subjects.
| ARMS-NP (n = 25) | ARMS-P (n = 8) | Group Comparison | |
|---|---|---|---|
| Male/female | 17/8 | 6/2 | χ2 = 0.14, p = 0.70, n.s. |
| Age (years) | 18.7 (3.8) | 20.5 (6.6) | p = 0.33, n.s. |
| JART | 98.1 (9.6) | 93.3 (11.1) | p = 0.25, n.s. |
| PANSS: positive symptom | 12.9 (4.1) | 13.8 (2.1) | p = 0.53, n.s. |
| negative symptom | 19.6 (8.0) | 19.2 (4.3) | p = 0.85, n.s. |
| general psychopathology | 34.1 (9.1) | 37.2 (8.4) | p = 0.40, n.s. |
| mGAF | 48.6 (9.0) | 41.7 (7.9) | p = 0.096, n.s. |
| SCoRS | 4.1 (1.9) | 6.6 (2.0) | p = 0.004 ** |
| BACS: verbal memory | −0.36 (1.4) | −1.1 (1.3) | p = 0.21, n.s. |
| working memory | −0.65 (1.1) | −1.70 (1.8) | p = 0.060, n.s. |
| motor function | −1.09 (1.8) | −2.02 (1.4) | p = 0.20, n.s. |
| verbal fluency | −0.78 (1.1) | −1.50 (1.4) | p = 0.16, n.s. |
| attention | 0.06 (1.5) | −1.12 (1.4) | p = 0.063, n.s. |
| executive function | −0.17 (0.96) | −0.94 (2.2) | p = 0.17, n.s. |
| composite score | −0.50 (0.94) | −1.40 (1.25) | p = 0.038 * |
| Amplitude (µV):T3 | 6.06 (3.0) | 6.30 (3.8) | p = 0.85, n.s. |
| T4 | 7.18 (3.9) | 4.37 (4.4) | p = 0.099, n.s. |
| Fz | 8.94 (6.6) | 6.96 (5.7) | p = 0.45, n.s. |
| Cz | 14.14 (6.0) | 9.79 (6.7) | p = 0.094, n.s. |
| Pz | 16.27 (5.2) | 13.76 (3.3) | p = 0.21, n.s. |
| Latency (msec):T3 | 318.9 (30.5) | 346.5 (31.8) | p = 0.039 * |
| T4 | 317.2 (40.0) | 329.0 (36.6) | p = 0.49, n.s. |
| Fz | 315.9 (35.7) | 344.7 (41.3) | p = 0.65, n.s. |
| Cz | 306.5 (34.5) | 342.7 (27.3) | p = 0.011 * |
| Pz | 307.7 (29.3) | 337.5 (33.3) | p = 0.022 * |
Values represent mean (SD). ARMS; at-risk mental state, ARMS-p; ARMS patients later transitioned to overt psychosis, ARMS-NP; ARMS patients who did not transition to overt psychosis, JART; Japanese Adult Reading Test, PANSS; Positive and Negative Syndrome Scale, mGAF; modified Global Assessment Functioning, SCoRS; Schizophrenia Cognitive Rating Scale, BACS; Brief Assessment of Cognition in Schizophrenia. P300 data represent peak amplitudes (µV) and latencies (msec) for each group [mean (SD)]. Demographic differences between groups were examined with Student’s t-test or the chi-square test (* p < 0.05, ** p < 0.01).