Fig 1. Swarm Framework: The Swarm architecture enables federated computation on genomic variants.

It classifies variant inquiry tasks into two main categories. “Stat Query” handles all queries that do not require data motion, and returns statistics such as counts of matched records and frequency of the alleles. “Data Query” handles queries that involve moving a set of records to another computing platform for further processing. In this figure, as an example, we illustrate the use of AWS Athena and GCP BigQuery.