Table 2. Databases used for annotating the 1000 Genomes data sets in this study.

Annotation Dataset Name	Reference
dbNSFP 35a	https://sites.google.com/site/jpopgen/dbNSFP
1000Genomes	https://www.internationalgenome.org/data/
RegulomeDB	https://www.regulomedb.org/regulome-search/
ClinVar	https://ftp.ncbi.nlm.nih.gov/pub/clinvar/vcf\_GRCh37/
UCSC gtex Eqtl Cluster	https://genome.ucsc.edu/gtex.html
gnomAD	https://gnomad.broadinstitute.org/downloads
Cosmic70	https://annovar.openbioinformatics.org/en/latest/user-guide/filter/#cosmic-annotations
Dann	https://annovar.openbioinformatics.org/en/latest/user-guide/filter/#dann-annotations
Eigen	https://annovar.openbioinformatics.org/en/latest/user-guide/filter/#eigen-score-annotations
eQTL & Diseases	http://www.exsnp.org/Download
GTEx Analysis v7 eQTL	https://gtexportal.org/home/datasets
SNP151	https://genome.ucsc.edu/cgi-bin/hgTrackUi?db=hg38\&g=snp151
Wellderly	https://genomics.scripps.edu/browser/files/wellderly/vcf