Fig 3. Correlation between the subunit ΔΔGbind values and the sum of ΔΔGbind,contribution of PTMs located in the respective protein chains.
Points above the grey line (y = x, with the surrounding grey area describing the error in subunit ΔΔGbind values) belong to systems in which the overall effect of PTMs on subunits’ binding is more destabilizing than could be expected based solely on local contributions of the PTMs, and the other way around for points below the grey line, both thanks to long-range effects. For systems described by points lying within the grey area, the local effect of PTMs does explain the overall effect on binding.