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. 2021 May 12;15(5):e0009400. doi: 10.1371/journal.pntd.0009400

Fig 4. Phylogeographic analysis of the L, M, and S segments of Hantaan virus (HTNV) collected from rodents and patients with hemorrhagic fever with renal syndrome (HFRS) in Republic of Korea (ROK).

Fig 4

(A) Geographic locations (circle symbols) indicate where the HTNV genomes were acquired in mainland and Jeju Island, ROK. The circle indicates geographic sites (a, Jeju; b, Jangheung; c, Paju; d, Yeoncheon; e, Pocheon; f, Cheorwon; g, Yanggu). Phylogenesis were generated by maximum-likelihood based on the alignment (Clustal W method) using the (B) 353-nucleotide L (coordinates 2,963–3,315 nt), (C) 369-nucleotide M (coordinates 1,973–2,341 nt), and (D) 639-nucleotide S (coordinates 412–1,050 nt) segments of HTNV. Topologies were evaluated using bootstrap analysis of 1,000 iterations. The following viral sequences were included in the analysis: HTNV ROKA13-8 (M segment, KU207202; S segment, KU207206), ROKA14-11 (L segment, KU207199; M segment, KU207203; S segment, KU207207), ROKA16-9 (L segment, MH598466; M segment, MH598480; S segment, MH598494), ROKA17-3 (L segment, MH598467; M segment, MH598481; S segment, MH598495), ROKA17-5 (L segment, MH598468; M segment, MH598482; S segment, MH598496), ROKA17-7 (L segment, MH598469; M segment, MH598483; S segment, MH598497), ROKA17-8 (L segment, MH598470; M segment, MH598484; S segment, MH598498), US8A14-2 (S segment, KU207208), US8A15-1 (L segment, KU207201), CUH15-126 (L segment, MG663537; M segment, MG663538; S segment, MG663539), Aa04-722 (L segment, KU2071740), Aa09-410 (L segment, KU207177), Aa09-948 (L segment, KT934966), Aa14-188 (M segment, KT935009), Aa15-56 (M segment, KU207187; S segment, KU207195), Aa15-58 (M segment, KU207188; S segment, KU207196), Aa17-7 (L segment, MH598475; M segment, MH598489; S segment, MH598503), Aa17-8 (L segment, MH598476; M segment, MH598490; S segment, MH598504), Aa17-48 (L segment, MH598477; M segment, MH598491; S segment, MH598505), Aa17-53 (L segment, MH598479; M segment, MH598493; S segment, MH598507), Aa18-179 (L segment, MT012580; M segment, MT012568; S segment, MT012556), Aa18-185 (L segment, MT012581; M segment, MT012569; S segment, MT012557), Ac19-6 (L segment, MW219756; M segment, MW219762; S segment, MW219768), Ac20-5 (L segment, MW219757; M segment, MW219763; S segment, MW219769), Ac20-6 (L segment, MW219758; M segment, MW219764; S segment, MW219770), Ac20-30 (L segment, MW219759; M segment, MW219765; S segment, MW219771), Ac20-31 (L segment, MW219760; M segment, MW219766; S segment, MW219772), Ac20-32 (L segment, MW219761; M segment, MW219767; S segment, MW219773), 76–118 (L segment, NC_005222; M segment, M14627; S segment, M14626), and SEOV 80–39 (L segment, NC_005238; M segment, NC_005237; S segment, NC_005236). Abbreviations; ROKA, Republic of Korea Army; US8A, United States 8th Army forces; CUH, Chosun University Hospital; Aa, Apodemus agrarius; Ac, A. chejuensis; SEOV, Seoul virus.