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. 2021 May 10;11:678559. doi: 10.3389/fonc.2021.678559

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Copyright © 2021 Anshabo, Milne, Wang and Albrecht

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sequence comparison between CDK9 and CDK2. The sequence identity between the two proteins is 31.9%. Green color indicates residues conserved between CDK9 and CDK2. Red underlined residues indicate the different functional subunits of the kinases. In the T-loop, the phosphorylation of a conserved threonine residue (labelled red) is vital for the activation of both CDK9 (Thr186) and CDK2 (Thr160). The sequence alignment was generated and % sequence similarity determined using UniProt (https://www.uniprot.org/align/) and sequence identifiers were P50750 for CDK9 and P24941 for CDK2.