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. 2021 Apr 21;9(5):891. doi: 10.3390/microorganisms9050891

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Integration breakpoint distribution in human chromosomes and HPV16 genome represented by Circos plots of the UCSC:SCC090 genome. (b) Breakpoint distribution percentage in HPV16 cell lines (UCSC:SCC090, UCSC:SCC152, UCSC:SCC154). (c) Categories of viral-host breakpoints; (1) Seamless transition with defined breakpoint. (2) Insertion; nucleotides that align to neither reference genome. (3) Breakpoint microhomology; nucleotides that align to both reference genomes.