Figure 3.

Schematic representation of TQ-induced HAUSP/UHRF1 deregulation and the related events. (A). In cancer cells, UHRF1 is protected from degradation through a direct interaction with HAUSP leading to epigenetic inhibition of TSGs which subsequently inhibits apoptosis. (B). Exposure of cancer cells to TQ induces a decrease in the expression of HAUSP which allows an autoubiquitination of UHRF1 through its E3 ubiquitin ligase activity as a first step for its degradation later inducing the reactivation of TSGs and apoptosis.