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. 2021 Apr 22;12(5):622. doi: 10.3390/genes12050622

Figure 4.

Figure 4

Schematic representation of TQ as a multitargeting single epidrug. TQ can directly inhibit the expression of UHRF1 protein leading to the inhibition of activity and/or activity of its partners DNMT1, HDAC1 and G9A. TQ could also target DNMT1, HDAC1 and G9A in UHRF1-indpendent mechanisms. DNMT1 inhibition leads to demethylation of TSG promoter. HDAC1 inhibition enhances the acetylation of histones 3 and 4. G9A inhibition causes demethylation of H3K9. All these TQ-induced effects lead to the reactivation of TSGs.