Table 1.
Significance of differentially abundant taxa and other variables between CF and matched controls. Columns indicate, in this order, the taxonomic level or the type of variable considered, the organism name or the variable name, the tendency of the difference in CF (↗: higher in CF, ↘: lower in CF, permanova results are not directional), the mean adjusted p-value of the statistical comparison between CF and matched controls, and the numbers of matched controls sub-samples for which the test is significant. Rows are ordered first by the tendency in CF samples, with organisms/variables that were greater in CF first, and then by mean adjusted p-value within each variable group
| Taxonomic level/variable | Organism/variable | Tendency in CF | Mean adjusted p value | Number of significant sub-sample tests |
|---|---|---|---|---|
| Genus | ||||
| Chryseobacterium | ↗ | 0.00199 | 100 | |
| Microbacterium | ↗ | 0.00231 | 100 | |
| Brevundimonas | ↗ | 0.00384 | 100 | |
| Blvii28 wastewater-sludge group | ↗ | 0.00847 | 98 | |
| Stenotrophomonas | ↗ | 0.00975 | 95 | |
| Streptococcus | ↗ | 0.0121 | 97 | |
| Rothia | ↗ | 0.0129 | 95 | |
| Staphylococcus | ↗ | 0.0130 | 92 | |
| Delftia | ↗ | 0.0138 | 93 | |
| Comamonas | ↗ | 0.0158 | 91 | |
| Unclassified at phylum level | ↗ | 0.0173 | 94 | |
| Scardovia | ↗ | 0.0207 | 90 | |
| Desulfobulbus | ↗ | 0.0257 | 87 | |
| F.Clostridiales_vadinBB60_group.UCG | ↗ | 0.0311 | 84 | |
| Mobiluncus | ↗ | 0.0318 | 83 | |
| Sphingobacterium | ↗ | 0.0325 | 82 | |
| Mogibacterium | ↗ | 0.0376 | 82 | |
| Peptostreptococcus | ↘ | 0.00853 | 97 | |
| F.Family_XIII.UCG | ↘ | 0.0106 | 97 | |
| Alloprevotella | ↘ | 0.0119 | 94 | |
| Treponema | ↘ | 0.0221 | 88 | |
| Aggregatibacter | ↘ | 0.0238 | 85 | |
| Parvimonas | ↘ | 0.0258 | 82 | |
| Bergeyella | ↘ | 0.0300 | 85 | |
| O.Saccharimonadales.UCG | ↘ | 0.0337 | 83 | |
| Fusobacterium | ↘ | 0.0436 | 69 | |
| Haemophilus | ↘ | 0.0611 | 51 | |
| Phylum | ||||
| Firmicutes | ↗ | 0.00575 | 100 | |
| Actinobacteria | ↗ | 0.00998 | 97 | |
| Spirochaetes | ↘ | 0.0157 | 93 | |
| Fusobacteria | ↘ | 0.0259 | 89 | |
| Patescibacteria | ↘ | 0.0796 | 49 | |
| Fungi | ||||
| Candida albicans | ↗ | 0.0310 | 82 | |
| Yeasts detected (Yes/No) | ↗ | 0.0765 | 61 | |
| Sialochemistry | ||||
| pH | ↘ | 0.0249 | 86 | |
| Alpha diversity | ||||
| Shannon diversity index | ↘ | 0.00199 | 100 | |
| Faith’s phylogenetic diversity | ↘ | 0.0000147 | 100 | |
| Species richness | ↘ | 0.0000145 | 100 | |
| Permanova (Beta diversity) | ||||
| Aitchison | - | 0.001 | 100 | |
| Jaccard | - | 0.001 | 100 | |
| Unweighted UniFrac | - | 0.001 | 100 | |
| Bray-Curtis | - | 0.00118 | 100 | |
| Weighted UniFrac | - | 0.0258 | 90 |