Table 3.

Associations of co-occurring taxa that differ between CF and matched control networks. The column ‘Association’ lists the co-occurring taxa. The column ‘Direction of correlation’ indicates the direction of that association. The final column shows the number of matched control networks (of the 100 sub-samplings that were performed) in which the correlation was significant

	Association	Direction of correlation	Significant co-occurrences among 100 control sub-samples
CF networks
	Alloprevotella +Brevundimonas	Negative	0
	Lactobacillus + Fusobacterium	Negative	0
	Lactobacillus + Gemella	Negative	0
	Aggregatibacter + Mesorhizobium	Negative	0
	Campylobacter + Leptotrichia	Positive	0
	Megasphaera + Kingella	Positive	0
	Corynebacterium + Selenomonas	Positive	0
Matched control networks
	Ralstonia + Variovorax	Positive	96
	Streptococcus + Gemella	Positive	92
	Prevotella + Veillonella	Positive	92
	Prevotella + Solobacterium	Positive	61
	Prevotella + Atopobium	Positive	50
	Bradyrhizobium +Hyphomicrobium	Positive	86
	Gemella + Granulicatella	Positive	72
	Actinomyces + Stomatobaculum	Positive	62
	Actinomyces + Rothia	Positive	58
	Actinomyces + Atopobium	Positive	46
	Rothia + Granulicatella	Positive	55
	F.Family_XIII.UCG + Parvimonas	Positive	50
	Treponema + Filifactor	Positive	47
	Treponema + Dialister	Positive	33