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PKP4 is a positive regulator of IKir2.1. Patch-clamping analyses in HEK293 cells upon genetic perturbation of PKP4, i.e. (A) upon overexpression of PKP4 and (B) upon CRISPR/Cas9-mediated depletion of PKP4. *P < 0.05 versus control. N: number of transfected cell batches; n: number of cells; OE: overexpression; KD: knock-down.
