Table 4.
Correlation of TGF-β1 with NLRP3, EMT markers, inflammation, and tumor size*
| Variables | TGF- 1 | N-cad | MMP9 | vimentin | E-cad | IL-1 | NLRP3 | ASC | Caspase1 | NF- B | Tumor size |
|---|---|---|---|---|---|---|---|---|---|---|---|
| TGF- 1 | 0.52 <0.001 |
0.268 0.082 |
0.569 <0.001 |
-0.39 0.01 |
0.19 0.223 |
0.268 0.082 |
0.248 0.109 |
0.22 0.157 |
0.296 0.054 |
0.397 0.008 |
|
| N-cad | 0.223 0.15 |
0.372 0.014 |
-0.396 0.009 |
0.145 0.355 |
0.28 0.069 |
0.087 0.578 |
0.113 0.469 |
0.448 0.003 |
0.379 0.012 |
||
| MMP9 | 0.273 0.077 |
-0.336 0.028 |
0.471 0.001 |
0.36 0.018 |
-0.08 0.607 |
0.179 0.251 |
0.205 0.188 |
0.157 0.315 |
|||
| Vimentin | -0.302 0.049 |
0.291 0.058 |
0.357 0.019 |
0.159 0.31 |
0.202 0.194 |
0.446 0.003 |
0.347 0.023 |
||||
| E-cad | -0.53 <0.001 |
-0.539 <0.001 |
-0.168 0.28 |
-0.169 0.27 |
-0.569 <0.001 |
0.508 0.001 |
|||||
| IL-1 | 0.685 <0.001 |
0.009 0.956 |
0.347 0.007 |
0.465 0.002 |
0.372 0.014 |
||||||
| NLRP3 | 0.12 0.443 |
0.186 0.232 |
0.572 <0.001 |
0.483 0.001 |
|||||||
| ASC | 0.124 0.429 |
0.369 0.015 |
0.223 0.151 |
||||||||
| Caspase1 | 0.163 0.298 |
0.163 0.295 |
|||||||||
| NF- B | 0.553 <0.001 |
ASC: Apoptosis-associated speck-like protein containing a CARD, E-cad: E-cadherin, IL-1β: interleukin-1β, N-cad: N-cadherin, MMP9: matrix metalloproteinase-9, NF κB: nuclear factor κB, NLRP3: NLR family pyrin domain containing 3, TGFβ: transforming growth factor-β. *In each cell upper number represents Pearson's correlation coefficient (r) and the lower number shows statistical significance (P-value). Negative numbers indicate inverse correlation between two variables