Table III.
Clinical trials of exosomes in patients with cancer.
| System | Cancer type | Study | Type | Intervention | Status |
|---|---|---|---|---|---|
| Respiratory system | NSCLC | Trial of a vaccination with tumor antigen-loaded dendritic cell-derived exosomes | Interventional | Biological: Dex2 | Phase I |
| Study of exosome EML4-ALK fusion in NSCLC clinical diagnosis and dynamic monitoring | Observational | Drug: ALK inhibitor | Recruiting | ||
| Lung cancer (diagnosis) | Serum exosomal long non-coding RNAs as potential biomarkers for lung cancer diagnosis | Observational | Diagnostic test: Collect samples | Recruiting | |
| Improving the early detection of lung cancer by combining exosomal analysis of hypoxia with standard of care imaging | Observational | Recruiting | |||
| Pulmonary nodules | Clinical study of ctDNA and exosome combined detection to identify benign and malignant pulmonary nodules | Observational | Diagnostic test: ctDNA and exosome combined detection | Recruiting | |
| Digestive system | Pancreatic cancer, benign pancreatic disease | Interrogation of exosome-mediated intercellular signaling in patients with pancreatic cancer | Observational | Blood, pancreatic fluid and pancreatic tissue | Recruiting |
| Diagnostic accuracy of circulating tumor cells and onco-exosome quantification in the diagnosis of pancreatic cancer-PANC-CTC | Observational | Procedure: Blood samples. Procedure: Portal vein blood sample |
Completed | ||
| iExosomes in treating participants with metastatic pancreas cancer with KrasG12D mutation | Interventional | Drug: Mesenchymal stromal cell-derived exosomes with KRAS G12D siRNA | Phase I | ||
| Pancreatic cancer | Circulating extracellular exosomal small RNA as potential biomarker for human pancreatic cancer | Interventional | Procedure: Venous sampling | Recruiting | |
| Colorectal cancer | Contents of circulating extracellular vesicles: Biomarkers in colorectal cancer patients | Observational | Biological: Analysis (protein, lipid, RNA) of circulating exosomes, size and number. Other: Gathering additional information about the cancer | Recruiting | |
| Rectal cancer | Exosomes in rectal cancer | Observational | Diagnostic Test: Blood Draw | Recruiting | |
| Urinary system | Clear cell renal cell carcinoma | Evaluation of urinary exosomes presence from clear cell renal cell carcinoma | Observational | Biological: Urinary sample | Recruiting |
| Reproductive system | Prostate cancer | Clinical validation of a urinary exosome gene signature in men presenting for suspicion of prostate cancer | Observational | Other: ExoIntelliScore prostate | Completed |
| Exosomal microRNA in predicting the aggressiveness of prostate cancer in Chinese patients | Observational | Recruiting | |||
| How does prostate cancer metastasize? Studying the role of secreted packages (exosomes) from fat tissue in lean and obese Patients | Observational | Procedure: Robotic Radical Prostatectomy | Recruiting | ||
| HER2-positive breast cancer | A study to measure the expression of the HER2-HER3 dimer in tumour and blood (exosomes) samples from patients with HER2-positive breast cancer receiving HER2-targeted therapies | Observational | Other: Acquisition of blood samples and tumor tissue samples (biopsies) | Recruiting | |
| Others | Oropharyngeal cancer | Exosome testing as a screening modality for human papillomavirus-positive oropharyngeal squamous cell carcinoma | Observational | None | Recruiting |
| Head and neck cancer | Metformin hydrochloride in affecting cytokines and exosomes in patients with head and neck cancer | Interventional | Radiation: External beam radiation therapy. Drug: Metformin hydrochloride. Other: Placebo |
Early phase I | |
| Sarcoma | Study of exosomes in monitoring patients with sarcoma (EXOSARC) | Observational | Biological: Blood samples | Recruiting | |
| Lung metastases osteosarcoma | Circulating exosome RNA in lung metastases of primary high-grade osteosarcoma | Observational | Diagnostic Test: ExoDx Prostate | Recruiting | |
| Lymphoma, B-cell, aggressive non-Hodgkin | Exosomes and immunotherapy in non-Hodgkin B-cell lymphomas | Interventional | Other: Blood sample | Recruiting |
NSCLC, non-small cell lung cancer; siRNA, small interfering RNA; ctDNA, circulating tumor DNA.