Table 5.
Univariate and multivariate analysis of variables related to transplant outcomes among all patients.∗
| Univariate analysis | Multivariate analysis | |||||
| Covariates | HR | 95% CI | P value | HR | 95% CI | P value |
| Relapse | ||||||
| Pre-MRD (positive vs. negative) | 2.724 | 1.824–4.068 | <0.001 | 1.576 | 1.031–2.409 | 0.036 |
| Risk score system | ||||||
| 0 | 1 | 1 | ||||
| 1 | 3.348 | 1.616–6.938 | 0.001 | 3.062 | 1.525–6.148 | 0.002 |
| 2 | 15.707 | 7.596–32.479 | <0.001 | 12.195 | 5.979–24.870 | <0.001 |
| 3 | 31.916 | 12.598–80.854 | <0.001 | 25.356 | 10.135–63.435 | <0.001 |
| Acute GVHD (yes or no) | 0.650 | 0.431–0.980 | 0.040 | |||
| LFS | ||||||
| Pre-MRD (positive vs. negative) | 1.605 | 1.153–2.234 | 0.005 | |||
| Risk score system | ||||||
| 0 | 1 | 1 | ||||
| 1 | 2.411 | 1.533–3.792 | <0.001 | 2.094 | 1.335–3.284 | 0.001 |
| 2 | 6.556 | 4.036–10.649 | <0.001 | 5.279 | 3.244–8.591 | <0.001 |
| 3 | 10.246 | 4.765–22.031 | <0.001 | 11.070 | 5.158–23.761 | <0.001 |
| Platelet engraftment (yes or no) | 0.060 | 0.037–0.098 | <0.001 | 0.079 | 0.048–0.129 | <0.001 |
| Acute GVHD III–IV (yes or no) | 1.751 | 0.993–3.091 | 0.053 | 1.854 | 1.048–3.282 | 0.034 |
| NRM | ||||||
| Pre-MRD (positive vs. negative) | 0.507 | 0.251–1.026 | 0.059 | |||
| Risk score system | ||||||
| 0 | 1 | |||||
| 1 | 1.856 | 1.037–3.322 | 0.037 | |||
| 2 | 0.256 | |||||
| 3 | 0.962 | |||||
| Platelet engraftment (yes or no) | 0.024 | 0.013–0.044 | <0.001 | 0.025 | 0.014–0.045 | <0.001 |
| Acute GVHD III–IV (yes or no) | 4.022 | 2.099–7.705 | <0.001 | 3.502 | 1.797–6.826 | <0.001 |
| OS | ||||||
| Pre-MRD (positive vs. negative) | 1.536 | 1.081–2.182 | 0.017 | |||
| Risk score system | ||||||
| 0 | 1 | 1 | ||||
| 1 | 2.311 | 1.425–3.748 | 0.001 | 2.109 | 1.295–3.433 | 0.003 |
| 2 | 6.565 | 3.936–10.949 | <0.001 | 5.262 | 3.118–8.880 | <0.001 |
| 3 | 8.412 | 3.735–18.949 | <0.001 | 9.533 | 4.221–21.527 | <0.001 |
| Platelet engraftment (yes or no) | 0.041 | 0.025–0.069 | <0.001 | 0.055 | 0.033–0.093 | <0.001 |
| Acute GVHD III–IV (yes or no) | 2.064 | 1.166–3.654 | 0.013 | 2.189 | 1.231–3.894 | 0.008 |
Results were calculated by Cox proportional hazards model.
∗
All variables were first included in the univariate analysis; only variables with P < 0.1 were included in the Cox proportional hazards model with time-dependent variables. CI: Confidence interval; GVHD: Chronic graft-versus-host disease; HR: Hazard ratio; LFS: Leukemia-free survival; MRD: Minimal residual disease; NRM: Non-relapse mortality; OS: Overall survival.