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. Author manuscript; available in PMC: 2021 May 24.
Published in final edited form as: Cell Syst. 2020 Mar 18;10(3):223–239.e9. doi: 10.1016/j.cels.2020.02.008

Fig.5. Inclusion of Treg/Th17 cells in the UC gut-liver MPS interaction leads to their conversion into inflammatory Th1/Th2 cells.

Fig.5

(A, C) Volcano plots of DEG in the gut MPSs (A) during interaction with the liver MPSs (C) in presence or absence of Treg/Th17 cells. (B, D) Network of enriched (magenta) and downregulated (blue) pathways based on KEGG in gut MPSs (B) or liver MPSs (D). (E) Clustered heatmap of multiplexed cytokines/chemokines present in circulating common media at day 4 during gut-liver MPS interaction +/- Treg/Th17 cells. (F) Significantly enriched metabolic pathways based on quantification of metabolites found in the common medium at day 4 of gut-liver-Treg/Th17 interactions. (G,H) Integration of significantly upregulated genes in the UC gut MPSs (G) or liver MPSs (H) during interaction with Treg/Th17 cells and enriched metabolites found in the common medium at day 4. Pathway impact score is shown on the x-axis and statistical significance on the y-axis. All data are derived from 3 biological replicates.