Table 2.
Effects of crude extract of H. abyssinica on castor oil-induced gastrointestinal motility.
| Dose administered | Length of small intestine (cm) | Distance moved by the charcoal meal (cm) | Peristaltic index (%) | % inhibition |
|---|---|---|---|---|
| Control | 57.10 ± 1.24 | 49.50 ± 1.43 | 86.70 ± 1.48 | — |
| 100 mg/kg | 58.60 ± 0.95 | 43.26 ± 3.73b3 | 73.80 ± 4.91b3 | 14.87 |
| 200 mg/kg | 59.00 ± 1.12 | 36.20 ± 1.45a2b3 | 61.35 ± 2.88a2b3 | 29.20 |
| 400 mg/kg | 57.16 ± 0.93 | 22.00 ± 1.32a3 | 39.85 ± 1.97a3 | 54.00 |
| Loperamide 3 mg/kg | 55.5 ± 1.51 | 15.83 ± 0.94a3 | 28.52 ± 1.08a3 | 67.10 |
Data are expressed as mean ± SEM (n = 6). aCompared to negative control. bCompared to loperamide 3 mg/kg. 1P < 0.05, 2P < 0.01, and 3P < 0.001. Negative controls received 10 ml/kg distilled water.