Table 4. Distribution of isolates, STs, NG-MAST types, resistance profiles and resistance genes and mutations at the seven sentinel sites. The genetic resistance mechanisms for all the isolates from each site are listed.

Laboratory	No. of isolates	STs (no. of isolates)	NG-MAST types (no. of isolates)	Resistance profile ± (no. of isolates)	Resistance genes and SNPs
CVM	1	8780	Novel	PEN CIP TCY	blaTEM, penA_ins346D, ponA1_L421P, mtrR_A39T, gyrA_S91F, gyrA_D95A, parC_S87N, tetM, rpsJ-V57M
DMC	1	1903	Novel	PEN CIP TCY	penA_ins346D, ponA1_L421P, porB1b_A121D, mtrR_promoter_ –57delA, gyrA_D95G, gyrA_S91F, parC_S87N, parC_E91K, tetM, rpsJ-V57M
EVR	1	1582	13 796	PEN CIP	blaTEM, penA_ins346D, mtrR_A39T, gyrA_D95G, gyrA_S91F, rpsJ-V57M
MMH	2	11 956, 11 208	1631, novel	PEN CIP	blaTEM, penA_ins346D, mtrR_A39T, porB1b_A121D, porB1b_G120K, gyrA_D95G, gyrA_S91F, parC_D86N, rpsJ_V57M
NMC	1	1588	Novel	PEN CIP TCY	blaTEM, penA_ins346D, mtrR_A39T, ponA1_L421P, gyrA_S91F, gyrA_D95A tetM, rpsJ-V57M
VSM	11	8133 (2), 9 364 (2), 10 316 (1), 1 587 (1), 11 431 (1), 11 963 (1), 1 582 (1), 11 956 (1), 15 234 (1)	2187(2), 1 691 (1), 1 498 (1),1797 (1), novel (6)	PEN CIP (4) PEN CIP TCY (4) CIP TCY (1) PEN (2)	blaTEM, penA_ins346D, mtrR_disrupted, mtrR_A39T, ponA1_L421P, porB1b_A121D, porB1b_G120K, gyrA_D95G, gyrA_D95A, gyrA_S91F, parC_D86N, parC_S87N, parC_E91K, tetM, rpsJ-V57M
ZPH	4	10 316 (2), 9 364 (1), 8 130 (1)	2080 (1), 11 821 (1), novel (2)	PEN CIP TCY (3) PEN CIP (1)	blaTEM, mtrR_disrupted, mtrR_A39T, porB1b_A121D, gyrA_D95G, gyrA_D95A, gyrA_S91F, parC_D86N, parC_S87N, parC_E91K, tetM, rpsJ-V57M

CVM: Cagayan Valley Medical Center; DMC: Southern Philippines Medical Center; EVR: Eastern Visayas Regional Medical Center; MMH: Corazon Locsin Montelibano Memorial Regional Hospital; NMC: Northern Mindanao Medical Center; VSM: Vicente Sotto Memorial Medical Center; ZPH: Zamboanga Del Norte Medical Center

PEN: penicillin, CIP: ciprofloxacin, TCY: tetracycline