Figure 4.
NPC-EVs enhance vessel-like tube formation of HUVECs in vitro and in vivo via transferring miR-144
(A) The number of vessel-like tubes formed in vitro. (B) Neovessels in the transplanted gel plugs containing EVs from C666-1 cells. (C) Neovessels in the transplanted gel plugs containing EVs from SUNE1 cells. ∗p < 0.05 by unpaired t test relative to HUVECs or transplanted gel plugs containing EVs from miR-mimic NC-treated NPC cells; #p < 0.05 by unpaired t test relative to HUVECs or transplanted gel plugs containing EVs from miR-inhibitor NC-treated NPC cells. n = 8 for each mouse group.