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The mechanistic illustration of pro-angiogenic function of tumor-secreted miR-144 in NPC
EVs secreted from NPC cells stimulate tumor angiogenesis via transferring miR-144. miR-144 negatively regulates FBXW7 and thus increases the activity of HIF-1α. Increased HIF-1α promotes the translation of VEGF-A, thereby facilitating endothelial cell migration and tube-forming ability.
