Table 2.
Histological and immunohistochemical characteristics
| Case no. | Fibrosis | Distribution of macrophages | Density of histiocytes | Cytoplasm of macrophages | Nuclei of macrophages | Giant cells | Phenotype |
| 1 | No | Superficial | Low | Foamy | Fine chromatin, nucleolated | Yes | S100–, CD163+, CD1a–, pERK+ |
| 2 | No | Superficial | Low | Eosinophil | Heterogenous | Yes | S100–, CD163+, CD68+, CD1a–, pERK+ |
| 3 | Yes | Superficial and deep | Moderate | Foamy | Small dense | No | S100–, CD163+, CD68+, CD1a–, pERK– |
| 4 | No | Superficial and deep | Moderate | Foamy | Small dense | No | S100–, CD163+, CD1a–, pERK– |
| 5 | No | Superficial | High | Foamy | Small dense | No | CD163+, CD68+, CD1a–, pERK– |
| 6 | No | Superficial and deep | High | Eosinophil | Small dense, folded | Yes | S100–, CD68+, CD1a–, pERK+ |
| 7 | No | Superficial and deep | Low | Foamy+eosinophil | Small dense | Yes | S100–, CD68+, CD1a– |
| 8 | No | Superficial | High | Foamy | Small dense | No | S100–, CD163+, CD68+, CD1a– |
| 9 | No | Superficial | Low | Eosinophil | Heterogenous | Yes | S100+, CD163+, CD1a–, pERK+ |
| 10 | Yes | Superficial and deep | Moderate | Foamy | Heterogenous | Yes | S100–, CD68+, CD1a– |
| 11 | Yes | NA (small sample) | Low | Foamy+eosinophil | Fine chromatin, nucleolated | No | CD163+, CD1a– |
| 12 | No | Superficial and deep | High | Foamy | Small dense | No | CD163+, CD68+, CD1a– |
| 13 | No | Superficial and deep | High | Foamy | Pleomorphic | Yes | S100–, CD163+, CD68+, CD1a–, pERK– |
| 14 | No | Deep | Moderate | Foamy | Fine chromatin, nucleolated | Non | S100+, CD163+, CD68+, CD1a–, pERK+ |
| 15 | No | Superficial | Low | Foamy+eosinophil | Heterogenous | Yes | S100–, CD163+, CD1a–, pERK– |
| 16 | No* | Superficial and deep | High | Foamy+eosinophil | Heterogenous | No | S100–, CD163+, CD1a–, pERK+ |
| 17 | Yes | NA (small sample) | High | Foamy | Small dense | No | S100–, CD163+, CD68+, CD1a– |
| 18 | Yes | Deep | Low | Eosinophil | Fine chromatin, nucleolated | Yes | S100+, CD163+, CD68+, CD1a–, pERK+ |
| 19 | Yes | Deep | Moderate | Foamy+eosinophil | Fine chromatin, nucleolated | Yes | S100–, CD68+, CD1a– |
| 20 | No | Deep | High | Foamy | Heterogenous | No | S100–, CD163+, CD68+, CD1a–, pERK+ |
| 21 | Yes | Superficial and deep | Moderate | Foamy+eosinophil | Heterogenous | No | S100–, CD163+, CD68+, CD1a–, pERK+ |
| 22 | No | Superficial and deep | Moderate | Foamy+eosinophil | Heterogenous | Yes | S100+, CD163+, CD68+, CD1a–, pERK+ |
*Cytosteatonecrosis associated.
NA, not analysable.