. Author manuscript; available in PMC: 2021 May 25.

Published in final edited form as: Am J Obstet Gynecol MFM. 2021 Jan 11;3(3):100308. doi: 10.1016/j.ajogmf.2021.100308

Table 4.

Studies evaluating the relationship between exposure to organic toxicants (perfluorooctane sulfonic acid and perfluorooctanoic acid) and preeclampsia.

First author’s last name and pub. year	Biologic or Environmental Specimen	Type of study	Sample size and population	Toxicant	Risk of Pre-E
Stein, 2009¹³³	Maternal serum	Retrospective cohort	1,845 (PFOA), 5,262 (PFOS) Mothers living in the Mid-Ohio Valley near Parkersburg, WV DuPont plant (C8 Health Project)	PFOS, PFOA	PFOA aOR=1.3, 95% CI (0.9, 1.9) for exposures above median PFOS aOR=1.3, 95% CI (1.1, 1.7) for exposures above median PFOS aOR=1.6, 95% CI (1.2, 2.3) above the 90^th percentile
Savitz, 2012¹³⁰	Maternal serum	Retrospective cohort	11,737 Mothers living in the Mid-Ohio Valley near Parkersburg, WV DuPont plant (C8 Health Project)	PFOA	OR=1.13, 95% CI (1.00, 1.26) for an interquartile shift in log-transformed PFOA. OR = 1.1-1.2 for upper three quartiles of exposure.