. Author manuscript; available in PMC: 2022 Jul 1.

Published in final edited form as: Respir Med. 2021 Apr 30;183:106434. doi: 10.1016/j.rmed.2021.106434

Table 3:

Subgroup analyses of association of obesity-related inflammatory pathways with lung function

	Adiponectin			Leptin			Resistin			IL-6			CRP			HOMA-IR
	beta	s.e.	p-value	beta	s.e.	p-value	beta	s.e.	p-value	beta	s.e.	p-value	beta	s.e.	p-value	beta	s.e.	p-value
Without lung disease N=421
FEV₁	0.05	0.77	0.95	−4.04	1.11	<0.0001	−0.30	0.81	0.71	−1.46	0.76	0.06	−1.76	0.81	0.03	−2.07	1.02	0.04
FVC	0.39	0.76	0.61	−3.50	1.11	0.002	−0.99	0.80	0.21	−1.36	0.75	0.07	−2.22	0.80	0.006	−2.10	1.03	0.04
FEV₁/FVC	−0.26	0.35	0.46	−0.46	0.52	0.38	0.72	0.37	0.05	−4E-4	0.35	0.99	0.68	0.37	0.07	−0.01	0.48	0.98
TLC	0.44	0.76	0.56	−5.16	1.02	<0.0001	0.31	0.81	0.70	−0.95	0.76	0.21	−1.29	0.81	0.11	−3.01	1.05	0.005
DLCO	0.11	1.10	0.92	−5.40	1.51	<0.0001	−1.76	1.18	0.14	−1.95	1.10	0.08	−2.53	1.18	0.03	−2.34	1.53	0.13
Restrictive lung disease N=98
FEV₁	−3.12	2.04	0.13	−1.79	3.16	0.57	−0.13	1.59	0.93	−1.98	1.84	0.29	−3.76	1.99	0.62	−6.84	3.22	0.04
FVC	−4.10	1.98	0.04	−0.77	3.1	0.80	0.13	1.56	0.93	−2.8	1.79	0.12	−3.04	1.96	0.13	−5.31	3.15	0.10
FEV₁/FVC	1.47	1.10	0.19	−1.85	1.69	0.28	0.13	0.86	0.87	1.04	0.99	0.30	−0.77	1.09	0.48	−1.80	1.82	0.33
TLC	−1.71	1.96	0.39	−5.09	3.00	0.10	0.87	1.54	0.57	−1.19	1.62	0.46	−1.72	1.79	0.34	−5.00	3.21	0.13
DLCO	−0.76	1.94	0.69	−1.65	3.06	0.59	−1.94	1.56	0.22	−0.05	1.65	0.98	1.04	1.89	0.60	−3.03	3.28	0.36
COPD N=174
FEV₁	0.37	1.95	0.85	−2.87	2.58	0.27	0.58	1.44	0.69	−5.51	1.54	<0.001	−3.98	1.67	0.02	−4.73	2.57	0.07
FVC	0.80	1.86	0.67	2.48	2.46	0.32	0.44	1.37	0.75	−5.01	1.47	0.001	−5.05	1.57	0.001	−4.75	2.46	0.06
FEV₁/FVC	−1.26	1.18	0.29	−1.10	1.57	0.48	0.61	0.87	0.49	−2.24	0.96	0.02	0.42	1.03	0.69	−0.63	1.55	0.69
TLC	1.20	2.27	0.60	−1.90	2.96	0.52	0.25	1.66	0.88	−1.71	1.76	0.33	−4.54	1.82	0.01	−3.81	2.79	0.18
DLCO	−0.35	2.38	0.88	−0.96	3.11	0.76	−0.26	1.74	0.88	−1.16	1.87	0.54	−4.28	2.00	0.03	−2.73	2.87	0.34

Multivariable model adjusted for age, sex, smoking status, previous MI, heart failure, and BMI. Units indicate difference in % predicted PFT per 1-SD change in log-transformed biomarker.

Abbreviations: FEV1, forced expiratory volume in one second; FVC, forced vital capacity; TLC, total lung capacity; DLCO, diffusion capacity of lungs for carbon monoxide; IL-6, interleukin-6; CRP, C-Reactive protein; HOMA-IR, homeostatic model assessment of insulin resistance