Table 4:

Association of obesity-related inflammatory pathways with cardiopulmonary exercise test (CPET) and pulmonary vascular (PV) parameters

	Adiponectin			Leptin			Resistin			IL-6			CRP			HOMA-IR
CPET parameters	beta	s.e.	p-value	beta	s.e.	p-value	beta	s.e.	p-value	beta	s.e.	p-value	beta	s.e.	p-value	beta	s.e.	p-value
Peak V02, ml/kg/min	0.08	0.18	0.67	−1.88	0.25	<0.0001	−0.53	0.16	0.001	−0.57	0.16	<0.0001	−0.87	0.17	<0.0001	−1.02	0.24	<0.0001
% pred VO2	0.20	0.74	0.79	−6.11	1.05	<0.0001	−2.36	0.67	<0.0001	−2.58	0.67	<0.0001	−3.54	0.72	<0.0001	−3.67	1.00	<0.0001
Work, watts	−2.31	1.55	0.14	−7.68	2.24	0.001	−4.16	1.42	0.003	−4.01	1.42	0.005	−5.90	1.52	<0.0001	−3.87	2.12	0.07
Peak RER	−0.005	0.005	0.33	0.02	0.008	0.009	0.003	0.005	0.52	−0.01	0.005	0.003	0.001	0.005	0.86	0.001	0.007	0.92
PETCO2 at AT	0.45	0.35	0.19	−0.43	0.54	0.42	−0.42	0.34	0.22	0.42	0.31	0.18	0.35	0.36	0.33	0.28	0.43	0.52
Breathing reserve	−1.34	0.88	0.13	0.23	1.29	0.86	1.44	0.81	0.08	0.31	0.83	0.71	−0.46	0.88	0.60	−0.77	1.22	0.53
Oxygen pulse	−0.28	0.11	0.01	−0.61	0.16	<0.0001	−0.12	0.10	0.24	−0.19	0.10	0.07	−0.40	0.11	<0.0001	−0.35	0.15	0.02
	Adiponectin			Leptin			Resistin			IL-6			CRP			HOMA-IR
PV Parameters	beta	s.e.	p-value	beta	s.e.	p-value	beta	s.e.	p-value	beta	s.e.	p-value	beta	s.e.	p-value	beta	s.e.	p-value
PAP/CO slope	0.31	0.14	0.03	−0.25	0.21	0.23	0.06	0.13	0.66	0.24	0.13	0.07	0.44	0.14	0.002	0.05	0.16	0.78
PCWP/CO slope	0.28	0.10	0.007	−0.19	0.15	0.21	0.03	0.10	0.73	0.12	0.09	0.20	0.30	0.10	0.003	−0.07	0.12	0.55
TPG/CO slope	0.03	0.09	0.71	−0.06	0.14	0.64	0.03	0.09	0.71	0.12	0.09	0.17	0.15	0.09	0.11	0.12	0.09	0.20
Pulm disten (alpha)	−0.09	0.04	0.05	0.03	0.06	0.62	−0.03	0.04	0.42	−0.12	0.04	0.003	−0.09	0.04	0.04	−0.08	0.06	0.21
PAC	−0.06	0.04	0.12	−0.11	0.06	0.05	−0.04	0.04	0.24	−0.12	0.04	0.001	−0.11	0.04	0.006	−0.13	0.05	0.02
RVEF (peak)	−1.70	0.40	<0.0001	1.68	0.58	0.004	−0.24	0.38	0.53	−0.76	0.36	0.04	−0.51	0.40	0.20	0.41	0.55	0.46

Multivariable model adjusted for age, sex, smoking status, previous MI, heart failure, and BMI

Abbreviations: VO2, peak oxygen consumption; VE/VCO2 slope, minute ventilation/carbon dioxide production; RER, respiratory exchange ratio; PETCO2 at AT, Postapneic End-Tidal Carbon Dioxide Pressure at Anaerobic Threshold; PAP/CO; pulmonary artery pressure/cardiac output; PCWP/CO; pulmonary capillary wedge pressure/cardiac output; TGP/CO, transpulmonary gradient pressure/cardiac output; PAC, pulmonary artery compliance; RVEF, Right ventricular ejection fraction; IL-6, interleukin-6; CRP, C-Reactive protein; HOMA-IR, homeostatic model assessment of insulin resistance