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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Oral Oncol. 2021 Apr 4;117:105270. doi: 10.1016/j.oraloncology.2021.105270

Figure 2. De novo gene fusion discovery confirms the EWSR1-ATF1 gene fusion structures in HCCC1 and HCCC2.

Figure 2.

A) RNAseq data from HCCC1 was analyzed using the FusionCatcher bioinformatics algorithm, which nominated an EWSR1-ATF1 fusion gene junction in this tumor. The junction was validated by PCR amplification of tumor-derived cDNA, followed by Sanger sequencing (top panel), structure of the fusion shown below. B) HCCC2 also harbored a characteristic EWSR1-ATF1 fusion gene, but with a unique structure from HCCC1.