Table 2.
Clinical outcomes of current POI treatments
| Treatment | Method | Number of patients recruited | Outcome |
|---|---|---|---|
|
Traditional in vitro activation (Kawamura et al. 2013 [22]) |
Laparoscopic unilateral ovary fragmentation followed by Akt in vitro stimulation for 2 days with subsequent transplantation of the ovary fragments in the contralateral ovary (two surgeries) | 27 POI | 2 pregnancies |
|
Simplified in vitro activation (Kawamura et al. 2020 [52]) |
Laparoscopic partial or complete cortex removal and unilateral fragmentation, followed by transplantation of the ovary fragments in the contralateral ovary (one surgery) | 11 POR/DOR | 4 pregnancies |
|
Transplantation of UCMSC on collagen scaffold (Ding et al. 2018 [19]) |
Intraovarian injection | 14 POF | 2 pregnancies |
|
Autologous BMSC therapy (Igboeli et al. 2020 [46]) |
Laparoscopic intraovarian injection | 2 POF | No pregnancy reported |
|
Autologous BMSC therapy (Edessy et al. 2016 [47]) |
Laparoscopic intraovarian injection | 10 POF | 1 pregnancy |
|
Autologous BMSC therapy (Gupta et al. 2018 [23]) |
Laparoscopic intraovarian injection | 1 POF | 1 pregnancy |
|
Autologous BMSC therapy (Gabr et al. 2016[48]) |
Laparoscopic intraovarian artery injection | 30 POF | 1 pregnancy |
|
Autologous BMSC therapy (Herraiz et al. 2018 [24]) |
Intraarterial catheterization to intraovarian artery (after 5 days of stem cell mobilization to peripheral blood and apheresis) | 15 POR | 5 pregnancies |
|
Autologous PRP treatment (Sills et al. 2018 [25]) |
Non-surgical transvaginal ultrasound-guided intraovarian injection | 4 POR | 1 pregnancy |
|
Autologous PRP treatment (Pantos et al. 2019 [26]) |
Non-surgical transvaginal ultrasound-guided bilateral intraovarian injection | 3 POF | 3 pregnancies |
|
Autologous PRP treatment (Sfakianoudis et al. 2019 [63]) |
Non-surgical transvaginal ultrasound-guided bilateral intraovarian injection | 3 POR | 3 pregnancies |
|
Autologous PRP and gonadotropin combination treatment (Hsu et al. 2020 [27]) |
Non-surgical transvaginal ultrasound-guided bilateral intraovarian injection | 1 POI | 1 pregnancy |
|
Autologous PRP treatment (Cakiroglu et al. 2020 [66]) |
Non-surgical transvaginal ultrasound-guided intraovarian injection | 510 POR | 43 pregnancies |
|
Autologous high-dose PRP treatment (Petryk et al. 2020 [67]) |
Laparoscopic-assisted technique intraovarian injection | 38 POR | 10 pregnancies |