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. 2021 Mar 1;28(6):1671–1687. doi: 10.1007/s43032-021-00496-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The impact of intrauterine administration of BoTA on fertility assessment. (a) Rates of stability of attached mouse embryos onto saline- or primed BoTA-treated Ishikawa cells at 19h, 24h, 28h, or 45h of co-culture. (b) A procedure of intrauterine BoTA administration. (c) Representative two images of mouse uterus including embryo implantation sites. (d) Average numbers of embryo implantation sites from 34 mouse uterus horns were assessed on embryonic day 16. (e) Representative images of mouse uterine arteries towards the sites of embryo implantation after open surgery. (f) Representative images of embryos (day 16) obtained from BoTA-treated or saline-treated mouse uterus. (g–h) Average weight of embryos obtained from BoTA-treated uterus compared to control. Data shown for (d) and (g) are from 3 independent experiments (# of mice, 17; # of embryos, 157) and analyzed using the paired Student t-test for parametric distributions including P-values (*<0.05, **<0.01, ***<0.001, NS not significant).