Table 2.

MiR-335 Regulates Cell Proliferation and Apoptosis in Various Cancer Types

Cancer Type	Downstream Target	Effect	Reference
Tyroid cancer	ICAM-1	Proliferation inhibition and Aoptosis induction	[50]
	SHH	Proliferation inhibition and Aoptosis induction67 accelerated cell apoptosis	[65]
NSCLC	BCL-W and SP1	Apoptosis induction	[19]
	Tra2β	Proliferation inhibition	[25]
	SOD2	Proliferation inhibition and apoptosis induction	[64]
	CUL4B	Apoptosis induction.	[62]
	CPNE1	Proliferation inhibition	[31]
	ROCK1	Proliferation inhibition	[30]
Gstric cancer	Survivin	Proliferation inhibition and Aoptosis induction.	[26]
	ROCK1	Proliferation inhibition	[58]
HCC	ROCK1	Proliferation inhibition	[39,57]
CRC	RASA1	Promotes proliferation	[20]
	LDHB	Proliferation inhibition	[43]
Gallbladder carcinoma	MEF2D	Promotes proliferation	[51]
Pancreatic cancer	JMJD2C	Proliferation inhibition and Apoptotic induction.	[68]
RCC	BCL-W	Proliferation inhibition	[44,60]
Bladder cancer	CRKL	Proliferation inhibition	[46]
	OCT4	Proliferation inhibition	[48]
Prostate cancer	EGR3	Proliferation inhibition and Aoptosis induction.	[47]
Ovarian cancer	BCL-W	Apoptotic induction.	[49]
Cervical Cancer	ROCK1	Proliferation inhibition	[56]
	PPP6C	Proliferation inhibition	[70]
Melanoma	ROCK1	Proliferation inhibition	[24]
Osteosarcoma	Survivin	Apoptotic induction	[37]
	ROCK1	Proliferation inhibition	[59]

Abbreviations: NSCLC, non-small cell lung cancer; ESCC, esophageal squamous cell carcinoma; CRC, colorectal cancer; HCC, hepatocellular carcinoma; RCC, renal cell carcinoma; EMC, endometrial cancer.