Table 3.
Multivariable Analysis of Associations Between Ocular and Systemic Factors with BCVA and CMT at 12 Months
| Variable | Regression Coefficient (95% CI) | P value |
|---|---|---|
| VA at 12 months | ||
| Baseline BCVA* | 6.4 (5.3, 7.4) | <0.001 |
| HbA1c ≥ 64 | 4.0 (1.3, 6.6) | 0.003 |
| Baseline CMT** | 14.4 (4.6, 24.3) | 0.01 |
| Presence of Epiretinal Membrane | −3.2 (−6.2, −0.1) | 0.04 |
| Retinopathy Status | ||
| R1 | 0 | 0.07 |
| R2 | 3.6 (0.4, 6.8) | |
| R3A | 0.4 (−3.7, 4.5) | |
| R3S | −1.1 (−7.3, 5.1) | |
| CMT at 12 months | ||
| Baseline CMT | 30 (20, 39) | <0.001 |
| Retinopathy Status | ||
| R1 | 0 | 0.007 |
| R2 | 2 (−19, 22) | |
| R3A | −40 (−67, −13) | |
| R3S | −13 (−53, 27) | |
Notes: *Regression coefficient reported for a 10-unit increase in VA; **Regression coefficient reported for a 100-unit increase in CMT.
Abbreviations: BCVA, best corrected visual acuity; CMT, central macular thickness; HbA1c, glycated haemoglobin; R1, mild and moderate non-proliferative diabetic retinopathy; R2, severe non-proliferative diabetic retinopathy; R3A, active proliferative diabetic retinopathy, R3S, stable treated proliferative diabetic retinopathy.