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. 2021 May 24;11:10749. doi: 10.1038/s41598-021-89781-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of EQ on large diameter myelinated sensory and motor nerve function. (A) Motor nerve conduction velocity in db/db-vehicle mice was significantly decreased (35.93 ± 1.9 m/s) compared to age-matched db/+ -vehicle mice (48.22 ± 3.8 m/s), but the velocity was improved with EQ treatment (43.91 ± 9.58 m/s in db/dv-EQ mice). Bars represent means ± SEM. (B) Amplitudes of compound muscle action potential (CMAP) was significantly reduced in 12-week-old db/db-vehicle mice. CAMP was significantly improved in db/db-EQ mice compared to db/db-vehicle mice (2.64 ± 0.35 mV in db/+ -vehicle mice, 2.16 ± 0.33 mV in db/db-EQ mice and 1.185 ± 0.14 mV in db/db-vehicle mice. n = 6 per group). Bars represent means ± SEM. (C) Sensory nerve conduction velocity was significantly decreased in db/db-vehicle mice (27.58 ± 0.95 m/s) compared to age-matched db/+ -vehicle mice (21.18 ± 1.79 m/s) and db/db-EQ mice (25.84 ± 0.86 m/s). Bars represent means ± SEM. (D) Amplitudes of sensory nerve action potential (SNAP) in tail nerves were not statistically different between groups.