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. 2021 May 24;11:10749. doi: 10.1038/s41598-021-89781-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Increase in mitochondrial DNA mutation deletions in the distal end of sciatic nerve was prevented by EQ treatment. Mitochondrial DNA mutation deletion was measured in the distal end of sciatic nerve and the apical cardiac tissue in db/+-vehicle (n = 8 per group), db/db-EQ (n = 5 per group) and db/db–vehicle mice (n = 8 per group). The deletion burden in distal end of sciatic nerve was higher in db/db-vehicle mice compared with db/+ -vehicle mice at 12 weeks age. This impairment was partially prevented with EQ treatment. However, the deletion burden in the apical cardiac tissue was not different among the groups. Bars represent means ± SEM.