Table 1.
Correlation and predictive measures for our sequencing assay, assuming ddPCR results as the gold standard.
| Del Ex 19 (%) | L858R (%) | T790M (%) | All ddPCR (%) | |
|---|---|---|---|---|
| Sensitivity (PPA) | 97.1 | 100.0 | 100.0 | 98.5 |
| Specificity (NPA) | 98.6 | 99.4 | 98.6 | 98.9 |
| PPV | 94.4 | 93.3 | 85.0 | 91.5 |
| NPV | 99.3 | 100.0 | 100.0 | 99.8 |
| Concordance | 98.4 | 99.4 | 98.7 | 98.8 |
Sensitivity and specificity of sequencing versus ddPCR are also shown in Fig. 6. A majority of discordant calls are supported by tissue, making the true sequencing specificity and PPV higher than the reported values vs. ddPCR.