Table 2.

Gene delivery vectors that have been used to over-express target gene(s) in stem cells to treat animal models of stroke

Delivered gene	Gene delivery vector(s) [Ref.]
BDNF	• Adenovirus pWEAxCAhBDNF-F/RGD [39, 40, 49] pShuttleCMV-BDNF [45] pAd-HM41-K7-BDNF-IE [46] • Retrovirus pBABE-BDNF [41, 44] pLXSN-BDNF-GFP [42] • Lentivirus [43]
NT-3	• Retrovirus pLIA-NT3 [47] • Lentivirus pGC-E1-hNT3 [48] • Adenovirus AxCAhNT3-F/RGD [49]
GDNF	• Adenovirus AxCAhGDNF-F/RGD [49, 50] pAdEasy-1-pAdTrack CMV-GDNF [51] • Non-viral plasmid [52, 53]
VEGF	• Herpes Simplex Virus 1764/4-/pR19/hVEGF165 [54] • Retrovirus pLPCX.VEGF [55] • Adenovirus pWEAxCAhVEGF-F/RGD [57]
CNTF	• Adenovirus AxCAhCNTF-F/RGD [49]
EGFL-7	• Adenovirus pAd-HM41-K7-EGFL7-IE [46]
Ang1	• Adenovirus pWAxCAhAng1-F/RGD [56, 57]
PIGF	• Adenovirus pWEAxCAhPlGF-F/RGD [58]
HIF1α	• Adenovirus [59, 61, 62] • Lentivirus Lv-mHIF-1α-EGFP [60] pCDH-CMV-HIF1-T2A-EGFP [71]
FGF	• Herpes Simplex Virus 1764/-4/pR19/ssIL2-FGF-2 [64] • Lentivirus [66] • Non-viral plasmid [65]
HGF	• Herpes Simplex Virus pR19ratHGFKT3WPRE [67]
Akt1	• Retrovirus pLHCX-Akt1 [69] • Lentivirus pCDH-CMV-Akt1-T2A-EGFP [71]
Bcl2/ Bcl-xl	• Non-viral plasmid [70] • Lentivirus pCDH-CMV-Bcl2-T2A-EGFP [71] pCDH-CMV-Bcl-xl-T2A-EGFP [71]
CXCR4	• Lentivirus pNL-CXCR4-IRES2-eGFP [72] • Adenovirus Ad5/35EF1α-CXCR4 [73]
IL-10	• Adeno-associated virus dsAAV1-CAG-IL-10 [75]
Survivin	• Lentivirus [76]
Persephin	• Adenovirus pAd-HM41-K7-PSP-IE [46]
Sonic hedgehog	• Adenovirus pAd-HM41-K7-SHH-IE [46]
MiR-133	• Lentivirus LentimiRa-GFP-hsa-miR-133b [77] • Non-viral plasmid [78]