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. 2021 May 11;8:627741. doi: 10.3389/fcvm.2021.627741

Table 5.

Prevalence of hypertension and phenotypes in Chinese children and adolescents, CHNS 1991–2015.

Variable 1991 (n = 2,429) 1993 (n = 2,254) 1997 (n = 2254) 2000 (n = 2217) 2004 (n = 1,364) 2006 (n = 1,145) 2009 (n = 1,012) 2011 (n = 1404) 2015 (n = 1,064) AAI (%) ARI (%) P for age-adjusted trend
Prehypertension (%, 95% CI)
Overall 7.0 (6.0–8.1) 7.5 (6.4–8.6) 8.5 (7.4–9.7) 9.2 (8.0–10.4) 9.9 (8.4–11.6) 9.2 (7.6–11.0) 11.3 (9.5–13.4) 9.9 (8.4–11.6) 13.0 (11.1–15.1) 0.3 3.6 <0.001
AGE GROUP
7–12 years 5.7 (4.6–7.1) 6.1 (5–7.6) 6.5 (5.3–7.9) 6.5 (5.3–8.1) 7.1 (5.4–9.1) 6.1 (4.6–8.2) 9.5 (7.5–12.1) 6.3 (4.9–8.1) 12.7 (10.6–15.2) 0.3 5.2 <0.001
13–17 years 8.6 (7.1–10.4) 9.2 (7.5–11.2) 11.6 (9.7–13.9) 12.3 (10.4–14.5) 12.4 (10.2–15.0) 13.4 (10.6–16.8) 14.0 (10.9–17.8) 15.8 (13.0–19.2) 13.7 (10.0–18.3) 0.2 2.5 <0.001
SEX
Male 6.6 (5.3–8.1) 7.5 (6.1–9.1) 8.7 (7.2–10.5) 9.5 (8.0–11.3) 11.7 (9.5–14.2) 9.5 (7.4–12.1) 11.9 (9.5–14.9) 11.8 (9.6–14.4) 13.3 (10.7–16.4) 0.3 4.3 <0.001
Female 7.5 (6.1–9.1) 7.4 (6.0–9.1) 8.3 (6.8–10.1) 8.7 (7.2–10.6) 7.9 (6.1–10.3) 8.8 (6.6–11.5) 10.4 (7.9–13.6) 8.0 (6.2–10.2) 12.6 (10.0–15.8) 0.2 2.9 0.001
Hypertension (%, 95% CI)
Overall 8.5 (7.4–9.7) 9.6 (8.5–10.9) 11.1 (9.9–12.5) 12.4 (11.1–13.8) 16.9 (15.0–18.9) 9.9 (8.3–11.7) 15.9 (13.8–18.3) 12.6 (11.0–14.4) 19.2 (16.9–21.7) 0.5 5.3 <0.001
AGE GROUP
7–12 years 4.5 (3.5–5.7) 8.0 (6.7–9.6) 8.1 (6.8–9.7) 9.9 (8.3–11.7) 13.2 (10.8–16) 6.3 (4.7–8.4) 16.3 (13.6–19.5) 11.3 (9.4–13.6) 18.2 (15.6–21.0) 0.6 12.7 <0.001
13–17 years 13.3 (11.5–15.5) 11.8 (9.9–14.0) 15.7 (13.5–18.3) 15.3 (13.3–17.7) 20.2 (17.4–23.3) 14.9 (11.9–18.3) 15.2 (12.0–19.1) 14.7 (11.9–18.0) 22.1 (17.6–27.5) 0.4 2.8 <0.001
SEX
Male 9.0 (7.5–10.7) 10.1 (8.5–12) 10.1 (8.5–11.9) 13.2 (11.4–15.2) 16.4 (13.9–19.3) 10.2 (8.8–12.8) 14.4 (11.7–17.6) 14.2 (11.8–16.9) 21.5 (18.3–25.1) 0.5 5.8 <0.001
Female 8.0 (6.6–9.7) 9.1 (7.5–11.0) 12.3 (10.5–14.5) 11.4 (9.6–13.5) 17.4 (14.7–20.5) 9.5 (7.3–12.3) 17.8 (14.5–21.6) 11.0 (8.9–13.6) 16.7 (13.7–20.2) 0.4 4.6 <0.001
Stage 1 hypertension (%, 95% CI)
Overall 8.0 (7.0–9.2) 9.1 (8.0–10.4) 10.6 (9.4–11.9) 11.7 (10.5–13.1) 16.0 (14.1–18) 9.7 (8.1–11.5) 14.6 (12.6–16.9) 12.3 (10.6–14.1) 17.7 (15.5–20.1) 0.4 5.0 <0.001
AGE GROUP
7–12 years 4.3 (3.3–5.5) 7.5 (6.2–9.1) 7.7 (6.4–9.3) 9.3 (7.8–11.1) 12.1 (9.8–14.8) 6.3 (4.7–8.4) 14.7 (12.1–17.7) 11.0 (9.1–13.2) 16.4 (14–19.1) 0.5 11.8 <0.001
13–17 years 12.6 (10.8–14.7) 11.1 (9.3–13.3) 14.8 (12.7–17.3) 14.7 (12.6–17.0) 19.5 (16.8–22.6) 14.4 (11.6–17.9) 14.5 (11.3–18.3) 14.3 (11.6–17.6) 21.4 (16.9–26.7) 0.4 2.9 <0.001
SEX
Male 8.7 (7.3–10.4) 9.4 (7.9–11.3) 9.8 (8.3–11.6) 12.4 (10.6–14.4) 15.6 (13.1–18.4) 9.9 (7.7–12.5) 13.2 (10.6–16.2) 13.7 (11.4–16.5) 20.4 (17.2–24.0) 0.5 5.6 <0.001
Female 7.3 (5.9–8.9) 8.7 (7.2–10.5) 11.4 (9.6–13.4) 11.0 (9.2–13.0) 16.5 (13.8–19.5) 9.5 (7.3–12.3) 16.4 (13.3–20.2) 10.7 (8.6–13.2) 14.8 (11.9–18.1) 0.3 4.3 <0.001
Stage 2 hypertension (%, 95% CI)
Overall 0.5 (0.3–0.8) 0.5 (0.3–0.9) 0.6 (0.3–1.0) 0.6 (0.4–1.1) 0.9 (0.5–1.5) 0.2 (0.0–0.7) 1.3 (0.7–2.2) 0.4 (0.1–0.9) 1.5 (0.9–2.4) 0.0 9.7 0.012
AGE GROUP
7–12 years 0.2 (0.1–0.7) 0.5 (0.2–1.0) 0.4 (0.2–0.9) 0.6 (0.3–1.2) 1.1 (0.5–2.3) 0.0 (0.0–0.0) 1.6 (0.9–3.0) 0.3 (0.1–1.1) 1.8 (1.0–3.0) 0.06 28.6 <0.001
13–17 years 0.7 (0.4–1.5) 0.6 (0.3–1.4) 0.9 (0.4–1.8) 0.7 (0.3–1.4) 0.7 (0.3–1.7) 0.4 (0.1–1.7) 0.8 (0.2–2.3) 0.4 (0.1–1.5) 0.7 (0.2–2.9) 0.0 0.0 0.589
SEX
Male 0.2 (0.1–0.7) 0.7 (0.3–1.4) 0.3 (0.1–0.8) 0.8 (0.4–1.5) 0.8 (0.4–1.8) 0.3 (0.1–1.3) 1.2 (0.6–2.6) 0.4 (0.1–1.3) 1.1 (0.5–2.4) 0.0 14.8 0.045
Female 0.7 (0.3–1.4) 0.4 (0.1–1.0) 0.9 (0.5–1.7) 0.5 (0.2–1.1) 0.9 (0.4–2.1) 0.0 (0.0–0.0) 1.3 (0.6–2.9) 0.3 (0.1–1.2) 1.9 (1.0–3.6) 0.1 7.8 0.110
ISH (%, 95% CI)
Overall 0.9 (0.6–1.4) 0.8 (0.5–1.3) 1.6 (1.1–2.2) 1.4 (0.9–1.9) 2.1 (1.5–3.0) 1.1 (0.7–1.9) 1.6 (1.0–2.6) 1.1 (0.7–1.9) 2.2 (1.4–3.2) 0.1 5.4 0.001
AGE GROUP
7–12 years 1 (0.6–1.8) 0.8 (0.4–1.5) 1.2 (0.7–2.0) 1.3 (0.8–2.1) 1.7 (0.9–2.9) 1.3 (0.7–2.6) 2.0 (1.1–3.5) 1.5 (0.9–2.8) 1.5 (0.7–2.9) 0.02 1.7 <0.001
13–17 years 0.8 (0.5–1.6) 0.8 (0.4–1.6) 2.0 (1.3–3.0) 1.4 (0.9–2.4) 2.6 (1.6–4.2) 0.9 (0.4–2.2) 1.1 (0.5–2.6) 0.7 (0.3–1.7) 2.9 (1.8–4.8) 0.1 10.1 0.932
SEX
Male 0.3 (0.1–0.8) 0.5 (0.3–1.1) 1.0 (0.6–1.7) 1.3 (0.8–2.2) 1.1 (0.5–2.3) 1.2 (0.6–2.4) 1.9 (1.1–3.4) 1.3 (0.7–2.3) 2.0 (1.2–3.3) 0.1 23.9 0.027
Female 1.7 (1.1–2.7) 1.1 (0.6–2.0) 2.3 (1.5–3.6) 1.4 (0.8–2.3) 3.1 (2.0–4.6) 1.0 (0.4–2.5) 1.0 (0.4–2.7) 0.9 (0.4–2.2) 2.6 (1.2–5.3) 0.0 2.0 0.021
IDH (%, 95% CI)
Overall 6.2 (5.3–7.2) 7.5 (6.5–8.7) 7.5 (6.5–8.7) 8.9 (7.8–10.1) 13.0 (11.3–14.9) 7.2 (5.8–8.8) 12.1 (10.2–14.2) 9.2 (7.8–10.8) 14.1 (12.1–16.3) 0.3 5.4 <0.001
AGE GROUP
7–12 years 3.6 (2.7–4.7) 6.1 (4.9–7.5) 4.9 (3.9–6.2) 6.1 (4.9–7.6) 10.5 (8.4–13.1) 3.1 (2.1–4.8) 11.7 (9.3–14.4) 7.8 (6.2–9.8) 12.6 (10.5–15.1) 0.4 10.5 <0.001
13–17 years 9.3 (7.7–11.2) 9.5 (7.8–11.5) 11.4 (9.5–13.6) 12.2 (10.3–14.3) 15.2 (12.7–18) 12.8 (10.1–16.1) 12.7 (9.7–16.4) 11.5 (9.1–14.5) 18.5 (14.3–23.5) 0.4 4.1 <0.001
SEX
Male 6.6 (5.4–8.2) 7.8 (6.4–9.5) 7.6 (6.3–9.3) 9.7 (8.1–11.5) 12.8 (10.5–15.4) 7.4 (5.6–9.8) 10.5 (8.2–13.3) 10.2 (8.2–12.7) 16.4 (13.5–19.7) 0.4 6.1 <0.001
Female 5.7 (4.5–7.2) 7.2 (5.8–8.9) 7.3 (5.9–9.1) 8.0 (6.5–9.8) 13.2 (10.8–16.0) 6.9 (5.0–9.4) 14.0 (11.1–17.5) 8.1 (6.3–10.4) 11.7 (9.1–14.7) 0.3 4.4 <0.001
SDH (%, 95% CI)
Overall 1.4 (1.4–1.9) 1.3 (0.9–1.8) 2.1 (1.6–2.8) 2.1 (1.6–2.8) 1.8 (1.2–2.6) 1.6 (1.0–2.5) 2.3 (1.5–3.4) 2.3 (1.6–3.2) 2.9 (2.1–4.1) 0.1 4.8 0.001
AGE GROUP
7–12 years 0.6 (0.3–1.2) 1.4 (0.9–2.2) 2.1 (1.5–3.1) 2.4 (1.7–3.4) 1.5 (0.8–2.9) 1.9 (1.1–3.3) 2.8 (1.7–4.4) 2.3 (1.5–3.5) 3.5 (2.4–5.1) 0.12 20.4 <0.001
13–17 years 2.3 (1.5–3.4) 1.1 (0.6–2.0) 2.0 (1.3–3.2) 1.8 (1.1–2.8) 1.9 (1.2–3.3) 1.0 (0.4–2.5) 1.5 (0.7–3.4) 2.3 (1.3–3.9) 1.1 (0.4–3.4) −0.1 −2.2 0.632
SEX
Male 1.3 (0.8–2.1) 1.5 (1.0–2.4) 1.3 (0.8–2.1) 2.2 (1.5–3.2) 1.9 (1.2–3.3) 1.5 (0.8–2.8) 2.0 (1.1–3.5) 2.4 (1.5–3.8) 3.6 (2.4–5.6) 0.1 7.7 0.002
Female 1.4 (0.9–2.3) 1.0 (0.6–1.8) 3.0 (2.1–4.2) 2.0 (1.3–3.1) 1.6 (0.8–2.9) 1.7 (0.9–3.2) 2.7 (1.5–4.6) 2.2 (1.3–3.6) 2.1 (1.2–3.8) 0.0 2.0 0.146

AAI, Average annual increase, AAI was computed by dividing the difference of prevalence between 1991 and 2015 by the number of years covered; ARI=Average relative increase, ARI was calculated by dividing the average annual change by the baseline prevalence in 1991; trends in prevalence from 1991 to 2015 were assessed by the generalized–estimating-equation method and adjusted by age and sex.