TABLE 2.
Circadian regulation of genes coding for proteins associated with Ca2+ signaling in Drosophila.
| Gene name | Description of the encoded protein | E-boxa | RevREb | Oscillates in central clockc |
| ip3r | IP3-sensitive Ca2+ channel localized to the ER | √ (120) | √ (4080) | Not described |
| pkc53E | Protein kinase that can be activated by Ca2+ | √ (4400) | √ (10920) | √ (LNd) |
| norpA | Protein kinase that can be activated by Ca2+ associated with phototransduction | √ (7900) | √ (3840) | √ (LNd) |
| camkii | Protein kinase that is regulated by the Ca2+/calmodulin complex | X | X | √ (LNd) |
| rack1 | Intracellular protein receptor for PKC | X | X | Not described |
| plc21c | Enzyme mediator of signal transduction through Ca2+ pathways | √ (1020) | √ (900) | √ (LNv) |
| serca | Ca2+ transporter ATPase from cytosol to ER | √ (480) | X | Not described |
| calcineurin B | Ca2+-dependent protein phosphatase involved signal transduction | X | X | √ (LNd/DN1) |
| cask | Protein kinase that regulates signal transduction in multiple pathways including Ca2+ | √ (7800) | √ (16680) | √ (LNd/DN1) |
| Ca2+α-1D | α subunit of an L-type voltage-gated Ca2+ channel expressed in neurons | X | √ (2700) | Not described |
| cacophony | Subunit of a voltage-gated Ca2+ channel located at presynaptic active zones | X | √ (1320) | √ (LNd) |
| ryr | Ca2+ release channel in the ER in response to depolarization of the cell | √ (2400) | X | Not described |
aNumber of base pairs upstream of the transcription start site where the E-BOX sequence (CACGTG) (Hao et al., 1997) is found.
bNumber of base pairs upstream of the transcription start site where the RevRE sequence (AGGTCA) (Preitner et al., 2002) is located.
cCircadian oscillation in levels of transcripts for genes in the central clock (specific neuronal group is indicated in parenthesis) according to database generated using RNAseq (Abruzzi et al., 2017). LN, lateral neuron cluster (v, ventral; d, dorsal); DN1, dorsal neuron cluster 1.