Table 1.
Hematology data from Wistar rats vaccinated with StreptInCor at different doses (50, 100 or 200 μg/mL) compared with placebo.
| Males | Placebo | 50 μg/mL | 100 μg/mL | 200 μg/mL |
|---|---|---|---|---|
| RBC (1012/L) | 9.36 ± 0.14 | 7.78 ± 0.13* | 8.34 ± 0.12 | 8.26 ± 0.20 |
| Hemoglobin (g/L) | 172.60 ± 6.33 | 145.80 ± 2.52 | 150.60 ± 2.77 | 154.50 ± 4.33 |
| Hematocrit (fraction) | 0.52 ± 0.02 | 0.44 ± 0.01 | 0.46 ± 0.01 | 0.45 ± 0.01 |
| MCV (fL) | 55.29 ± 1.51 | 56.40 ± 1.02 | 54.92 ± 1.06 | 54.89 ± 0.73 |
| MCH (pg) | 18.43 ± 0.50 | 18.76 ± 0.28 | 18.07 ± 0.45 | 18.70 ± 0.18 |
| MCHC (g/L) | 333.30 ± 0.21 | 332.70 ± 2.04 | 329.00 ± 2.23 | 340.80 ± 2.33 |
| Platelets (109/L) | 910.80 ± 116.40 | 913.50 ± 51.40 | 856.20 ± 85.00 | 773.90 ± 123.00 |
| Leukocytes (109/L) | 6.03 ± 0.75 | 5.50 ± 0.35 | 7.46 ± 0.76 | 5.36 ± 0.42 |
| Lymphocytes(109/L) | 4.97 ± 0.63 | 4.52 ± 0.32 | 6.14 ± 0.67 | 4.26 ± 0.33 |
| Monocytes (109/L) | 0.13 ± 0.01 | 0.12 ± 0.01 | 0.13 ± 0.01 | 0.10 ± 0.01 |
| Granulocytes (109/L) | 0.94 ± 0.16 | 0.86 ± 0.05 | 1.19 ± 0.15 | 1.01 ± 0.11 |
| Lymphocytes (fraction) | 0.82 ± 0.02 | 0.82 ± 0.01 | 0.82 ± 0.02 | 0.80 ± 0.02 |
| Monocytes (fraction) | 0.02 ± 0.00 | 0.02 ± 0.00 | 0.02 ± 0.00 | 0.02 ± 0.00 |
| Granulocytes (fraction) | 0.15 ± 0.02 | 0.16 ± 0.01 | 0.16 ± 0.02 | 0.19 ± 0.02 |
| Females | Placebo | 50 μg/mL | 100 μg/mL | 200 μg/mL |
| RBC (1012/L) | 7.65 ± 0.01 | 7.77 ± 0.26 | 7.53 ± 0.19 | 7.78 ± 0.19 |
| Hemoglobin (g/L) | 141.20 ± 1.24 | 142.00 ± 3.05 | 136.60 ± 2.98 | 144.00 ± 2.70 |
| Hematocrit (fraction) | 0.42 ± 0.01 | 0.43 ± 0.01 | 0.41 ± 0.01 | 0.43 ± 0.01 |
| MCV (fL) | 54.54 ± 0.18 | 55.24 ± 0.72 | 54.99 ± 0.38 | 55.10 ± 0.58 |
| MCH (pg) | 18.46 ± 0.13 | 18.29 ± 0.27 | 18.15 ± 0.11 | 18.54 ± 0, 21 |
| MCHC (g/L) | 338.50 ± 1.88 | 331.20 ± 1.27 | 330.10 ± 1.65 | 336.60 ± 1.78 |
| Platelets (109/L) | 802.00 ± 48.14 | 947.40 ± 93.40 | 769.60 ± 52.30 | 800.80 ± 112.20 |
| Leukocytes (109/L) | 4.08 ± 0.37 | 7.40 ± 0.47* | 2.44 ± 0.38 | 4.15 ± 0.30 |
| Lymphocytes (109/L) | 3.16 ± 0.30 | 6.00 ± 0.40* | 1.78 ± 0.34 | 3.41 ± 0.29 |
| Monocytes (109/L) | 0.09 ± 0.01 | 0.13 ± 0.01 | 0.06 ± 0.00 | 0.06 ± 0.00 |
| Granulocytes (109/L) | 0.84 ± 0.17 | 1.26 ± 0.07 | 0.60 ± 0.06 | 0.68 ± 0.03 |
| Lymphocytes (fraction) | 0.77 ± 0.03 | 0.81 ± 0.05 | 0.71 ± 0.05 | 0.81 ± 0.01 |
| Monocytes (fraction) | 0.02 ± 0.00 | 0.02 ± 0.00 | 0.024 ± 0.00 | 0.02 ± 0.00 |
| Granulocytes (fraction) | 0.21 ± 0.03 | 0.17 ± 0.00 | 0.27 ± 0.05 | 0.17 ± 0.01 |
Each value represents the mean ± SEM of placebo, StreptInCor at 50, 100 and 200 μg/mL. RBC, red blood cells; MCV, mean cell volume; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration. Dunn's Multiple Comparison test:
*
significant differences: males- StreptInCor (50 μg/mL) and placebo (p < 0.05) and leukocytes and lymphocytes from females treated with StreptInCor (50 μg/mL) and placebo (p < 0.05).