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. 2021 May 24;11:10802. doi: 10.1038/s41598-021-90198-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Microbiological analysis of saliva and plaque samples from caries free (CF), caries experienced—no recurrence (CE-NR), and active recurrent caries (CR) groups. Panels A and B depict Mutans streptococci and Candida spp. counts in saliva samples and in healthy plaque (H), white spot lesion plaque (WS) and cavitated dentin plaque (D) from the study groups, respectively. The CFU counts among the three caries status groups were compared using general linear mixed modeling, controlling by age. Data shown are mean ± SD values of log total colony count of Mutans streptococci and Candida spp. colonies.