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. 2021 May 24;11:10791. doi: 10.1038/s41598-021-89931-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of MDR1 and ABCG2 in the liver cancer stem cell (LCSC) population of Huh7 and PLC/PRF/5 cells. (a) The gating of viable cells using forward scatter (FSC) and side scatter (SSC). (b) The percentage of MDR1⁺ and ABCG2⁺ expression in the bulk tumor population. (c1,d1) The percentage of LCSC markers EpCAM and CD133 in the bulk tumor population. The cells shown in (c1) and (d1) were divided into four quadrants (Q1, Q2, Q3 and Q4). (c2–c5,d2–d5) The expression of MDR1 and ABCG2 in the cells from Q1, Q2, Q3 and Q4 of (c1) and (d1) was determined. The Huh7 and PLC/PRF/5 cells were stained with IgG isotype-matched control antibodies of (e) EpCAM and CD133 and (f) MDR1 and ABCG2. Horizontal and vertical axes denote expression intensity. One representative experiment of three is shown.