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. 2021 May 24;11:10791. doi: 10.1038/s41598-021-89931-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Involvement of MDR1 and ABCG2 in doxorubicin (DOX) efflux as determined by pharmacological inhibitors. The Huh7 or PLC/PRF/5 cells were treated with 200 nM or 100 nM of DOX in the presence or absence of MDR1 inhibitor valspodar (1 µM) or ABCG2 inhibitor ko143 (1 µM) for 24 h followed by flow cytometric analysis. (a) Percentage of DOX-positive cells; (b) DOX intensity followed by indicated treatments. Data shown are means ± SD, (n = 3). ****p < 0.0001; ***p < 0.001; **p < 0.01; *p < 0.05; compared with DOX treatment.