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. 2021 May 24;11:10731. doi: 10.1038/s41598-021-90200-y

Figure 3.

Figure 3

PDVC57 tumors grow in immunocompetent mice, unlike PDV tumors. (A) PDV tumors regress at approximately two weeks in immunocompetent B6 mice while PDVC57 continue to grow. (B) Both PDV and PDVC57 tumors continue to grow without regression in immunodeficient Rag1 KO mice. (C) Kaplan–Meier survival curves of PDV and PDVC57 in either B6 or Rag1 KO mice. Mantel-Cox test demonstrated significantly different survival curves, P < 0.0001. Post-hoc analysis demonstrates that in B6 mice, there exists a significant difference between PDV and PDVC57 tumors (P < 0.0001), while in Rag1 KO mice, there is no significant difference between PDV and PDVC57 tumors. (D) Endpoint tumor weights of PDV and PDVC57 in either B6 or Rag1 KO mice. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 in (A), (B), and (D) using the unpaired t-test adjusted for multiple comparisons. Two separate experiments with n > 10 per group.