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. 2021 May 24;11:10825. doi: 10.1038/s41598-021-90402-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Reactivity of human sera against C. albicans mannan and BSTO. Reactivity against C. albicans mannan (a) as detected by ELISA (Platelia Candida Ab test), and against BST-3β-Man (b), as detected by multi-analyte profiling (MAP) analysis. Human sera consisted of sera from healthy controls (blood donors presenting no disease), and ICU patients either not-infected or infected with C. albicans. Anti-C. albicans mannan antibody response is shown for infected patients according to antigenemia status (negative: open symbols; positive: closed symbols) (b). The correlation between anti-mannan and 2α-Man, 2β-Man, 3β-Man antibodies is shown in (c, d, e) respectively. The values of Spearman rank correlation coefficients for the different BSTOs are given in f.