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. 2021 May 24;11:313. doi: 10.1038/s41398-021-01415-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Fluorescently labelled phalloidin and DNAse show the amount of filamentous and globular actin, respectively. B Quantification of fluorescence intensity shows Cyfip1^+/− cells have an increased F- to G-actin ratio. C Treatment with Arp2/3 inhibitors CK-548 or CK-666 in wild-type cells significantly reduces the distance moved by cells during live imagine, whereas treatment of Cyfip1^+/− cells restores distances to wild-type levels.